Bontril Chemical Basis
Bontril (Phendimetrazine tartrate) has the chemical
name of (+)-3,4-Dimethyl-2-phenylmorpholine Tartrate.
Phendimetrazine tartrate is white
in color with any odor, with bitter taste in the
form of powder. It is soluble in methanol, water
and ethanol.
Phendimetrazine tartrate has the
pharmacological activity that is the same as the
activity of the prototype drugs of the same class
that are used in obesity.
They are called amphetamines. Phendimetrazine
tartrate is used to stimulate central nervous
system and to elevate the blood pressure. All
the drugs of this class are found to have tolerance
and tachyphylaxis that is commonly found in all
the drugs that are used for the same purpose.
Phendimetrazine tartrate and other drugs of this
class are commonly called anorectics or anorexigenics.
Still, the function of Phendimetrazine tartrate
is not established as to decrease the body weight
and to suppress appetite.
There is a possibility of the involvement
of metabolic effects or central nervous system.
It is found that magnitude of weight loss is increased
among drug treated patients as compared to the
magnitude of weight loss among placebo treated
patients but this difference is only a fraction
of a pound a week.
It is also found that the weight
decreases quickly in the first weeks among the
patients that are treated over both the drug and
placebo. Then the rate of weight decrease drops
in the following weeks.
Variations are found in the weight
loss due to Phendimetrazine tartrate from trial
to trial and it is suggested that the significant
decrease in the weight in the first weeks is probably
due to variables rather than the drug.
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