Prevacid Description, Chemistry, Ingredients
The
main ingredient of Prevacid lansoprazole. The
description, chemistry and Ingredients of lansoprazole
are as follows:
The active ingredient in lansoprazole delayed-release
capsules is a substituted benzimidazole, 2-[[[3-methyl-4-(2,2,2-trifluroethoxy)-2-pyridyl]methyl]sulfinyl]
benzimidazole, a compound that inhibits gastric
acid secretion. Its empirical formula is C16H14F3N3O2S
with a molecular weight of 369.37.
Lansoprazole is a white to brownish-white
odorless crystalline powder which melts with
decomposition at approximately 166°C. Lansoprazole
is freely soluble in dimethylformamide; soluble
in methanol; sparingly soluble in ethanol; slightly
soluble in ethyl acetate, dichloromethane and
acetonitrile; very slightly soluble in ether;
and practically insoluble in hexane and water.
Lansoprazole is stable when exposed
to light for up to two months. The compound
degrades in aqueous solution, the rate of degradation
increasing with decreasing pH. At 25°C the
t½ (half-life) is approximately 0.5 hour
at pH 5.0 and approximately 18 hours at pH 7.0.
Prevacid is supplied in delayed-release
capsules for oral administration. The delayed-release
capsules contain the active ingredient, lansoprazole,
in the form of enteric-coated granules and are
available in two dosage strengths: 15 mg and
30 mg of lansoprazole per capsule. Each delayed-release
capsule contains enteric-coated granules consisting
of lansoprazole, hydroxypropyl cellulose, low
substituted hydroxypropyl cellulose, colloidal
silicon dioxide, magnesium carbonate, methacrylic
acid copolymer, starch, talc, sugar sphere,
sucrose, polyethylene glycol, polysorbate 80,
and titanium dioxide. Components of the gelatin
capsule include gelatin, titanium dioxide, D&C
red no. 28, FD&C blue no. 1, FD&C green
no. 3 (Prevacid 15 mg capsules only), and FD&C
red no. 40.
|
